REDUCTASES FOR XENOBIOTIC CARBONYL COMPOUNDS. REDUCTASES FOR XENOBIOTIC CARBONYL COMPOUNDS. Structures and Specificities of the Human Liver Enzymes
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چکیده
منابع مشابه
Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: relationship with multiple forms of drug ketone reductases.
Multiple forms of reductases for several drug ketones were isolated from rabbit liver, but their interrelationship and physiologic roles remain unknown. We isolated cDNAs for four aldo-keto reductases (AKR1C30, AKR1C31, AKR1C32, and AKR1C33), which share high amino acid sequence identity with the partial sequences of two rabbit naloxone reductases. The four recombinant enzymes reduced a variety...
متن کاملMetabolism of bupropion by carbonyl reductases in liver and intestine.
Bupropion's metabolism and the formation of hydroxybupropion in the liver by cytochrome P450 2B6 (CYP2B6) has been extensively studied; however, the metabolism and formation of erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. The purpose of this investigation was to compare the relative contribution of the two metabolism pathway...
متن کاملStructural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases
UNLABELLED Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on endogenous compounds such as steroids or eicosanoids. One of the major carbonyl reducing...
متن کاملCloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases.
The genes encoding flavin mononucleotide-containing oxidoreductases, designated xenobiotic reductases, from Pseudomonas putida II-B and P. fluorescens I-C that removed nitrite from nitroglycerin (NG) by cleavage of the nitroester bond were cloned, sequenced, and characterized. The P. putida gene, xenA, encodes a 39,702-Da monomeric, NAD(P)H-dependent flavoprotein that removes either the termina...
متن کاملNovel photolabile protecting group for carbonyl compounds.
[reaction: see text] A novel type of photo-protecting group for carbonyl compounds is described. The protecting group is readily accessed in one step from commercially available material. Installation of the protecting group upon the carbonyl compounds is achieved in excellent yields. The carbonyl compounds in their protected form are remarkably stable under various conditions and can be releas...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1994
ISSN: 0916-1139
DOI: 10.2133/dmpk.9.supplement_192